Schizophrenia is typically characterized by negative symptoms including apathy and impaired executive function while positive symptoms refer to delusions and hallucinations. Appreciating the role of B vitamins, and particularly folate, the metabolism of which is dictated by genetic variants such as MTHFR, the potential for meaningful intervention grows.
- 140 subjects were randomized to receive 400ug of B12 plus 2mg of folic acid vs placebo.
- Improvement in negative symptoms was greater in the treatment group but correlated specifically to genetic variants related to folate metabolism.
- This study may be an example of nutrigenomics or implementing therapeutic use of nutrients related to personalized need.
Read the methylation and schizophrenia study here.